VDR is a Virtual Data Room that provides secure and reliable access to confidential documents for business transactions. VDRs can be used to perform due diligence during mergers and acquisitions. They also assist businesses organize important documents and share them with investors and other stakeholders. VDRs can also be used to store and organize invoices, contracts and other documents, for legal purposes such as litigation or estate planning.

Members should review their current article procedures and equipment fitted to their vessels with VDR/S-VDRs installed. It is also recommended to replace and upgrade those that are inefficient or do not meet the minimum safety requirements.

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the expression of proteins that are involved in a myriad of physiological processes.

The VDR can be located in cells of glial origin, and subsets of them that are part the brain. In the primary hippocampal cells of rats, VDR immunoreactivity was detected in the oligodendrocytes. The VDR is also found in human neuroblastoma and astrocytes. Treatment of HL-60 myeloblast leukemia cells with 1,25(OH)2D3 led to monocyte-like differentiation that was accompanied by an increase in the levels of VDR protein. This effect was prevented by inhibitors of PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.